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We need more studies like CATIE - says Principal Investigator

... "However, almost three quarters of patients changed treatments - so although treatments work, but there are clear limitations in their effectiveness.""Olanzapine was slightly better than the other drugs in terms of symptom control and prevention of relapse, but it did so at a substantial cost in terms of side effects.

It had the highest rate of discontinuation for side effects, particularly weight gain and metabolic disturbances," he added.According to Dr Lieberman, the major surprise of the initial results (New England Journal of Medicine 2005:353;1209-1223) was that perphenazine was comparably effective to three of the four new medications s...

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